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  • Label-free automated three-dimensional imaging of whole organs by microtomy-assisted photoacoustic microscopyThree-dimensional (3D) optical imaging of whole biological organs with microscopic resolution has remained a challenge. Most versions of such imaging techniques require special preparation of the tissue specimen. Here we demonstrate microtomy-assisted photoacoustic microscopy (mPAM) of mouse brains and other organs, which automatically acquires serial distortion-free and registration-free images with endogenous absorption contrasts. Without tissue staining or clearing, mPAM generates micrometer-resolution 3D images of paraffin- or agarose-embedded whole organs with high fidelity, achieved by label-free simultaneous sensing of DNA/RNA, hemoglobins,
  • A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cellsDisruption of the reprogrammed energy management system of malignant cells is a prioritized goal of targeted cancer therapy. Two regulators of this system are the Fer kinase, and its cancer cell specific variant, FerT, both residing in subcellular compartments including the mitochondrial electron transport chain. Here, we show that a newly developed inhibitor of Fer and FerT, E260, selectively evokes metabolic stress in cancer cells by imposing mitochondrial dysfunction and deformation, and onset of energy-consuming autophagy which decreases the cellular ATP level. Notably, Fer was also found to associate with PARP-1 and E260 disrupted this association thereby leading to PARP-1 activation. The cooperative intervention with these metabolic pathways leads to energy crisis and necrotic death in malignant, but not in normal human cells, and to the suppression of tumors growth in vivo. Thus, E260 is a new anti-cancer agent which imposes metabolic stress and cellular death in cancer cells.
  • Multifunctional nanoparticles as a tissue adhesive and an injectable marker for image-guided procedures组织粘合剂作为缝合和钉扎的一种替代品,用于外科手术或创伤后伤口闭合和损伤组织的重新连接。由于这些粘合剂的方便性和有效性,特别是在微创手术中,这些粘合剂受到越来越多的关注。
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厦门大学分子影像暨转化医学研究中心 福建省分子影像诊疗工程技术研究中心 厦门市分子影像工程技术研究中心 版权所有
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