聂立铭/Liming Nie

                                                      

                                                             聂立铭,特聘研究员,博士生导师

       聂博士紧密围绕光声成像、分子影像研究主线,在自主研制并改进光声显微镜技术、开发基于超高灵敏光声检测的多模态探针、早期光声监测肿瘤新生血管和治疗疗效等方面取得了重要突破。

       在国际高水平SCI期刊已发表论文40余篇。其中Nat. Comm.、Adv. Mat.、Opt. lett.、Chem. Soc. Rev.等权威杂志的通讯作者/第一作者身份论文近30篇。部分工作被Nat. Methods、Nat. Photon.、Chem. Rev.等杂志高频次引用和亮点评价,总引用>1500次,得到国际同行高度积极评价。

       作为项目负责人主持两项国家自然科学基金,主持一项科技部863子项目,主持一项厦门大学“校长基金”。以项目骨干身份参与一项科技部973项目。共申请中国/美国专利6项,2项已获授权,其中光声显微镜专利已在企业进行产业技术转化。

      获福建省第二批引进高层次人才(2015年)、浙江省‘千人计划’特聘专家(2016年)。2016年获Acs Nano Young Scientist Award。在SPIE、OSA、NIH等知名学术机构举办的国际会议受邀大会报告6次。担任Advanced Materials、Biomedical Optics Express、IEEE Transaction on Medical Imaging等众多国际知名期刊审稿人。
    
研究方向:
1. 高分辨率光声显微镜自主研制与技术改进;

2. 国际前沿的光学、光声成像技术在肿瘤、心血管病、脑创伤等重大疾病的早期诊断、监测;

3. 智能化、功能化、可控化诊疗分子探针的设计合成及其在高灵敏度、高特异性检测中应用;

4. 核磁共振、超声、正电子发射等联合光声成像形成多模态多尺度成像。

职位信息:招聘硕士、博士研究生,有意应聘者敬请将个人简历发送至邮箱。
通信地址:厦门市翔安区翔安南路厦门大学分子影像大楼(曾辉楼)311室      邮编:361102
电话/传真:0592-2880642
电子邮箱:nielm at xmu.edu.cn

 

Selected publications (*corresponding author)

  1. 1. Li W., Chen R., Lv J., Wang H., Peng Y., Qian Y. Fu G., and Nie L.*, “In vivo photoacoustic imaging of brain injury and rehabilitation by high-efficient NIR dye labeled mesenchymal stem cells with enhanced brain barrier permeability,” Advanced Science, 10.1002/advs.201700277, (2017)

  2. 2. Huang X., Shi Y., Liu Y., Xu H., Y. Liu, Xiao C., Ren J. & Nie L.*, “Noninvasive photoacoustic identification and imaging of gut microbes,” Optics Letters, 42(15): 2938-2940 (2017). (Equal contribution)

  3. 3. Zhou Z., Tian R., Wang Z., Yang Z., Liu Y., Liu G., Wang R., Gao J., Song J.*, Nie L.* & Chen X.*, “Artificial local magnetic field inhomogeneity enhances T2 relaxivity,” Nature Communications 8, 15468 doi: 10.1038/ncomms15468 (2017).

  4. 4. Zhou Z., Song J., Tian R., Yang Z., Yu G., Lin L., Zhang G., Fan W., Zhang F., Niu G., Nie L.*, & Chen X.*, “Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy,” Angew. Chem. Int. Ed.129(23): 6592-6596 (2017).

  5. 5. Zhou Z., Bai R., Munasinghe J., Shen Z., Nie L.*, and Chen X.*, “T1–T2 Dual-Modal Magnetic Resonance Imaging: From Molecular Basis to Contrast Agents,” Acs Nano, 11(6): 5227–5232  (2017).

  6. 6. Liu Y., Yang Y., Sun M., Cui M., Fu Y., Lin Y., Li Z.*, and Nie L.*, “Highly specific noninvasive photoacoustic and positron emission tomography of brain plaque with functionalized croconium dye labeled by a radiotracer,” Chemical Science, 8: 2710-2716, (2017).  (IF 9.1)

  7. 7. Zhou Z., Song J., Nie L.*, and Chen X.*, “Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy,” Chem. Soc. Rev. 45(23): 6597-6626, (2016)  (IF 34)

  8. 8. Zhao Q., Dai C., Fan S., Lv J. & Nie L.*, “Synergistic efficacy of salicylic acid with a penetration enhancer on human skin monitored by OCT and diffuse reflectance spectroscopy,” Scientific Reports. 6, 34954, doi: 10.1038/srep34954 (2016).   (IF 5.2)

  9. 9. Shi S., Liu Y., Chen Y., Zhang Z., Ding Y., Wu Z., Yin J.*, and Nie L.*, “Versatile pH-response Micelles with High Cell-Penetrating Helical Diblock Copolymers for Photoacoustic Imaging Guided Synergistic Chemo-Photothermal Therapy,” Theranostics. 6(12): 2170-2182, (2016).  (IF 8.8)

  10. 10. Li W.*, Y. Liu, J. Wu, Z. Qian, and Nie L.* “Tumor cells injury by magnetic nanoparticles under ultrasound,” Nanomedicine: Nanotechnology, Biology, and Medicine 12, 449–575, (2016)

  11. 11. Liu Y., Kang N., Lv J., Zhou Z., Zhao Q., Ma L., Chen Z., Ren L.*, and Nie L.*, “Deep photoacoustic/optical/magnetic resonance multimodal imaging in living subjects using high-efficient upconversion nanocomposites,” Advanced Materials. 28: 6411-6419, (2016)   (IF 18.96)

  12. 12. Song J., Wang F., Yang X., Ning B., Harp M., Culp S., Hu S., Huang P., Nie L., Chen J., Chen X., "Gold Nanoparticle Coated Carbon Nanotube Ring with Enhanced Raman Scattering and Photothermal Conversion Property for Theranostic Applications," J. Am. Chem. Soc. 138 (22): 7005–7015, (2016)   (IF 13)

  13. 13. Kang N., Liu Y., Zhou Y., Wang D., Chen C., Ye S., Nie L.* and Ren L.*, “Phase and Size Control of Core–Shell Upconversion Nanocrystals Light up Deep Dual Luminescence Imaging and CT In Vivo,” Advanced Healthcare Materials. 5 (11): 1356-1363, (2016)   (IF 5.76)

  14. 14. Liu Y., Nie L.*, Chen X.*, “Photoacoustic molecular imaging: from multiscale biomedical applications towards early-stage theranostics,” Trends in Biotechnology. 34(5): 420–433, (2016)   (IF 12)

  15. 15. Liu Y., He J., Yang K., Yi C., Liu Y., Nie L., Khashab N. M., Chen X. and Nie Z., “Folding Up of Gold Nanoparticle Strings into Plasmonic Vesicles for Enhanced Photoacoustic Imaging,” Angewandte Chemie. 127(52): 16035-16038. (2015)  (IF 11.7)

  16. 16. Song K., Huang P., Yi C., Ning B., Hu S., Nie L., Chen X., and Nie Z., “Photoacoustic and Colorimetric Visualization of Latent Fingerprints,” Acs Nano. 9 (12): 12344–12348.  (2015)   (IF 13.3)

  17. 17. Tang Y., Hu H., Zhang M. G., Song J., Nie L., Wang S., ... & Chen X., “An aptamer-targeting photoresponsive drug delivery system using “off–on” graphene oxide wrapped mesoporous silica nanoparticles,” Nanoscale. 7(14): 6304-6310. (2015)   (IF 7.76)

  18. 18. Li W., Xing L., Tao L., Qian Z., and Nie L.*, “In vivo monitoring of blood-brain barrier leakage by using photoacoustic microscopy,” IEEE, Biomedical Circuits and Systems Conference (BioCAS), 93-96. (2014)

  19. 19. Nie L.*, Huang P., Li W., Yan X., Jin A., Wang, Z. et al. “Early-Stage Imaging of Nanocarrier-Enhanced Chemotherapy Response in Living Subjects by Scalable Photoacoustic Microscopy,” Acs Nano. 8(12): 12141-12150. (2014)  (IF 13.3)

  20. 20. Hu H., Huang P., Weiss O., Yan X., Yue X., Zhang M., Tang Y., Nie L., Ma Y., Niu G., Wu K., Chen X.*, “PET and NIR optical imaging using self-illuminating 64Cu-doped chelator-free gold nanoclusters,” Biomaterials. 35(37): 9868-9876. (2014)   (IF 8.38)

  21. 21. Li W., Sun X., Wang Y., Niu G., Chen X., Qian Z., & Nie L.* “In vivo quantitative photoacoustic microscopy of gold nanostar kinetics in mouse organs,” Biomedical Optics Express. 5(8): 2679-2685. (2014)

  22. 22. Nie L. and Chen X.*, “Structural and functional photoacoustic molecular tomography aided by emerging contrast agents,” Chem. Soc. Rev. 43 (20): 7132-7170. (2014)  (IF 34)

  23. 23. Huang P., Rong P., Lin J., Li W., Yan X., Zhang M., Nie L., Niu G., Lu J., Wang W., Chen X.*, “Triphase Interface Synthesis of Plasmonic Gold Bellflowers as Near-infrared Light Mediated Acoustic/Thermal Theranostics,” J. Am. Chem. Soc. 136(23): 8307–8313. (2014)  (IF 13)

  24. 24. Nie L., Wang S., Wang X., Rong P., Ma Y., Liu G., Huang P., Lu G.*, Chen X.*, “In vivo Volumetric Photoacoustic Molecular Angiography and Therapeutic Monitoring with Targeted Plasmonic Nanostars,” Small. 10(8): 1585-1593. (2014)  (IF 8.4)

  25. 25. Rong P., Yang K., Srivastan A., Kiesewetter D. O., Yue X., Wang F., Nie L., Bhirde A., Wang Z., Liu Z., Niu G., Wang W., Chen X., “Photosensitizer Loaded Nano-Graphene for Multimodality Imaging Guided Tumor Photodynamic Therapy,” Theranostics. 4(3): 229-239. (2014)   (IF 8.8)

  26. 26. Yang K., Zhu L., Nie L., Sun X., Cheng L., Wu C., Niu G., Chen X.*, Liu Z.*, “Visualization of protease activity in vivo using an activatable photo-acoustic imaging probe based on CuS nanoparticles,” Theranostics. 4(2): 134-141. (2014)  (IF 8.8)

  27. 27. Nie L., Chen M., Sun X., Rong P., Zheng N., Chen X.*, “Palladium nanosheets as highly stable and effective contrast agents for in vivo photoacoustic molecular imaging,” Nanoscale. 6(3): 1271-1276. (2014)   (IF 7.8)

  28. 28. Lalwani G., Cai X., Nie L., Wang L. V.*, Sitharaman B.*, “Graphene-based contrast agents for photoacoustic and thermoacoustic tomography,” Photoacoustics. 1(3): 62-67. (2013).

  29. 29. Huang C., Wang K., Nie L., Wang L. V.*, Anastasio M. A*. “Full-Wave Iterative Image Reconstruction in Photoacoustic Tomography with Acoustically Inhomogeneous Media,” IEEE Trans. Med. Imaging. 32(6): 1097-1110. (2013)   (IF 3.8)

  30. 30. Wang Z., Zhang X., Huang P., Zhao W., Liu D, Nie L., Yue X., Wang S., Ma Y., Kiesewetter D., Niu G., Chen X. “Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging,” Biomaterials. 34(26): 6194-6201. (2013)   (IF 8.6)

  31. 31. Wang S., Huang P., Nie L., Xing R., Liu D., Wang Z., & Chen X et al. “Single Continuous Wave Laser Induced Photodynamic/Plasmonic Photothermal Therapy Using Photosensitizer‐Functionalized Gold Nanostars,” Adv. Mater. 25(22): 3009-3009. (2013)  (IF 17.5)

  32. 32. Sun Z., Huang P., Tong G., Lin J., Jin A., Rong P., Zhu L., Nie L. et al, “VEGF-loaded Graphene Oxide as Theranostics for Multi-Modality Imaging-Monitored Targeting Therapeutic Angiogenesis of Ischemic Muscle,” Nanoscale. 5: 6857-6866. (2013).  (IF 7.4)

  33. 33. Nie L., Cai X., Maslov K., Garcia-Uribe A., Anastasio M. A., and Wang L. V.*, “Photoacoustic tomography through a whole adult human skull with a photon recycler,” J. Biomed. Opt. 17(11): 110506. (2012). (†Equal contribution)  (IF 2.85)

  34. 34. Huang C., Nie L., Schoonover R. W, Guo Z., Schirra C., Anastasio M. A., Wang L. V.*, “Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data,” J. Biomed. Opt. 17(6): 066016. (2012). (†Equal contribution) 

  35. 35. Huang C., Nie L., Schoonover R. W, Wang L. V., Anastasio M. A., “Photoacoustic computed tomography correcting for heterogeneity and attenuation,” J. Biomed. Opt. 17(6): 061211. (2012). (†Equal contribution) 

  36. 36. Nie L., Guo Z., Wang L. V., “Photoacoustic tomography of monkey brain using virtual point ultrasonic transducers,” J. Biomed. Opt. 16(7): 076005. (2011).

  37. 37. Lou C., Nie L., D Xu, “Effect of excitation pulse width on thermoacoustic signal characteristics and the corresponding algorithm for optimization of imaging resolution,” J. Appl. Phys. 110(8): 083101. (2011).

  38. 38. Nie L., Ou Z., Yang S., Xing D.*, “Thermoacoustic molecular tomography with magnetic nanoparticle contrast agents for targeted tumor detection,” Med. Phys. 37(8): 4193-4200. (2010).  (IF 3.0)

  39. 39. Cao C., Nie L., Lou C, Xing D.*, “The feasibility of using microwave-induced thermoacoustic tomography for detection and evaluation of renal calculi,” Phys. Med. Bio. 55(17): 5203-5212. (2010).

  40. 40. Nie L., Xing D.*, Yang S., “In vivo detection and imaging of low-density foreign body with microwave-induced thermoacoustic tomography,” Med. Phys. 36(8): 3429-3437. (2009). 

  41. 41. Nie L., Xing D.*, Zhou Q., Yang D., Guo H. “Microwave-induced thermoacoustic scanning CT for high-contrast and noninvasive breast cancer imaging,” Med. Phys. 35(9): 4026-4032. (2008).

  42. 42. Nie L., Xing D.*, Yang D., Zeng L., Zhou Q., “Detection of foreign body using fast thermoacoustic tomography with a multielment linear transducer array,” Appl. Phys. Lett. 90: 174109-174111.  (2007).  (IF 3.5)

  43. 43. Nie L., Xing D., “Imaging calibration of thermoacoustic tomography distortion caused by microwave diffraction.” Proc. SPIE 7519, 75190N1-9.  (2009).

  44. 44. Lou C., Xing D., Nie L., “Fast microwave-induced thermoacoustic tomography and the application in biomedicine,” Acta Laser Biology Sinica 17 (4), 530-534. (2008).

  45. 45. Nie L.*, Guo H., “Thermoacoustic and photoacoustic imaging of biological tissue with different contrasts and properties,” Proc. SPIE 7280, 72801N1-9. (2009)

 

专利

1, Wang L. V., Nie L., Cai X., Maslov K., Anastasio M. A., Huang C., “Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data,” US Patent 20,150,245,771. (2015)

2,聂立铭、陈小元 《一种生物组织光声共聚焦显微成像装置及方法》  发明专利    授权号 201410210043.2, (2016)

3, 聂立铭、吴志友、李宏辉、赵庆亮 《一种光声显微镜及其监测微泡在生物组织中爆破的方法》专利号 201710267504.3, 申请日 2017.04.21

4,聂立铭、周子健 《基于混合组分磁性纳米颗粒组装体的磁共振造影剂及制备》 专利号 201710166770.7, 申请日 2017.03.20

5,周子健、聂立铭《酸敏感可控释放单线态氧纳米材料及其制备方法与应用》 专利号 201710166778.3, 申请日 2017.03.20

6,聂立铭、曾吕明、纪轩荣、向良忠、朴忠烈、杨迪武 《皮下血管网络的光声成像身份识别装置及其识别方法》 专利号 201611006087.9, 申请日 2016.11.16

7,纪轩荣、曾吕明、聂立铭、向良忠、朴忠烈、杨迪武 《高分辨率光声显微成像身份识别系统及其识别方法》 专利号 201611006088.3, 申请日 2016.11.16

厦门大学分子影像暨转化医学研究中心 福建省分子影像诊疗工程技术研究中心 厦门市分子影像工程技术研究中心 版权所有
地址:福建省厦门市翔安区翔安南路厦门大学曾辉楼,邮编:361102
电话:0592-2880646,邮箱:xiamen-cmitm@xmu.edu.cn