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Lecture on "Tissue optics and optical clearing technologies"

Oct 24, 2016 923 Views

      Speaker: Valery Tuchin, Professor, Saratov National Research State University, Russian Federation

Date: October 24, 2016

Time: 10:00 am

Location: 101 Conference room, School of Public Health, Xiamen University,

Inviter: Xianzhong Zhang, Professor; Qingliang Zhao, Ph.D.

Abstract:

This lecture presents fundamentals and advances of tissue optical clearing. The technology is based on controlling of tissue optical properties by using immersion technique via application of exogenous optical clearing agents (OCAs). Impact of OCA and water transport in a tissue, caused by an action of a hyperosmotic OCA and leading to tissue reversible shrinkage and dehydration, on temporal tissue optical properties, is discussed. The specific features of optical clearing of fibrous and cell-structured tissues are investigated using different linear and nonlinear optical modalities in the UV, visible, NIR and terahertz ranges. In vitro, ex vivo, and in vivo studies of a variety of human and animal tissues, including skin, eye sclera, muscle, cerebral membrane, digestive tract tissue, cartilage, bone, blood vessels, and blood are presented. The technologies of delivery of OCAs are also under discussion, including hidden free diffusion, enforced tissue permeability, and via blood and lymph vessel networking. Impact of different OCAs on tissue structure, free/bound water balance and microcirculation are analyzed. Experimental results on diffusivity of glucose and other biocompatible clearing agents in normal and pathological tissues are presented.

Bio: Valery V. Tuchin is a professor and chairman of Optics and Biophotonics at Saratov National Research State University. He is also the head of laboratory, Institute of Precision Mechanics and Control, RAS, and the supervisor of Interdisciplinary laboratory of Biophotonics at National Research Tomsk State University. His research interests include biophotonics, tissue optics, laser medicine, tissue optical clearing, and nanobiophotonics. He is a member of SPIE, OSA, and IEEE, Guest Professor of HUST (Wuhan) and Tianjin Universities of China, and Adjunct Professor of the Limerick University (Ireland) and National University of Ireland (Galway). He is a fellow of SPIE and OSA, and has been awarded Honored Science Worker of the Russia, SPIE Educator Award, OSA/SPIE Joseph W. Goodman Book Writing Award, FiDiPro (Finland), and Chime Bell Prize of Hubei Province (China).