刘刚，1979年7月生，四川隆昌人，现为厦门大学公共卫生学院教授、博士生导师，担任中国生物医学工程学会理事、中国生物材料学会理事、中华医学会放射学分会分子影像学组副组长。

刘刚教授发挥其理工医学科交叉研究背景，围绕肿瘤精准诊疗的关键科学和技术问题，聚焦分子影像探针功能设计的系统研究，于2014年获得国家自然科学基金委的优秀青年科学基金资助。研究成果先后获得2016年国家科技进步二等奖（排名第6）、2016年福建省自然科学三等奖（排名第 1）、2012年四川省科技进步一等奖（排名第2）及第十一届四川省青年科技奖。作为通讯作者在JCR一区主流期刊如Nat Commun、JACS、Adv Mater等杂志发表论文60余篇（影响因子高于10的论文37篇）并入选科睿唯安（Clarivate）2019年度全球“高被引科学家”榜单。参编全国高校规划教材3部、英文专著11部。获得国家专利授权7项，其中2项进行了企业技术转移及临床转化。

通信地址：厦门市翔安区翔安南路厦门大学公共卫生学院分子影像大楼308

邮编：361102

电话/传真：0592-2880648

电子邮箱: gangliu.cmitm@xmu.edu.cn

研究兴趣:分子影像探针、生物医用高分子、药物/基因传输体系

课题组主页：https://gangliu.xmu.edu.cn

获奖情况:

南充市科技进步一等奖(2005)；四川省科技进步二等奖(2006)；MRS Outstanding Symposium Paper (2009)；四川省杰出青年学术技术带头人培育计划(2011)；第11届四川省青年科技奖(2011)；四川省科技进步一等奖(2012)；福建省高等学校新世纪优秀人才支持计划(2013)；厦门市重点人才(2014)；国家自然科学基金优秀青年科学基金(2014)。
Dr. Gang Liu is a professor at Xiamen University in China. He received his MD degree from North Sichuan Medical College (China) in 2002 and PhD degree from Sichuan University (China) in 2009. Subsequently, He focused his training on nanomedicine and molecular imaging at the National Institutes of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) under the supervision of Dr. Xiaoyuan Chen (2009-2011). In 2012, Dr. Liu joined the Center for Molecular Imaging and Translational Medicine (CMITM), Xiamen University. He is now working in the field of Biomedical Engineering to develop various bio-inspired nanomaterials for cancer theranostic. His scientific work has been published as 75 papers in prestigious journals (Adv. Mater., Account Chem. Res., ACS Nano, Angew. Chem. Int. Ed., Biomaterials, Biotechnol. Adv., Chem. Soc. Rev., Nano Today, Nat. Commun., Small, etc.), 8 invited book chapter, and 7 patents. The awards he received include IMRC Outstanding Symposium Paper (Materials Research Society, 2008), Distinguished Young Investigator Award (Sichuan Province, 2011), Youth Science and Technology Award (Sichuan Province, 2011), Natural Science Award (First-class, Sichuan Province, 2012), New Century Excellent Talents in University Award (Fujian Province, 2013), New Century Excellent Talents in University Award (Ministry of Education of China, 2013), Excellent Young Scientists (NSFC, 2014). Now he is serving as editorial board members for several journals including Am J Nucl Med Mol Imaging and Quant Imaging Med Surg.

2013年至今文章发表情况(*通讯作者)：

2015

1.Xiangzhao Ai, Chris Jun Hui Ho, Junxin Aw, Amalina Binte Ebrahim Attia, Jing Mu, Yu Wang, Xiaoyong Wang, Yong Wang, Xiaogang Liu, Huabing Chen, Mingyuan Gao, Xiaoyuan Chen, Edwin K. L. Yeow, Gang Liu*, Malini Olivo*, and Bengang Xing*. In vivo Covalent Cross-linking of Photon-converted Rare-earth Nanostructures for Tumor Localization and Theranostics. Nature Communications. 2015, DOI: 10.1038/ncomms10432. (IF 11.47)

2.Pengfei Zhang#, Yixin Chen#, Yun Zeng#, Chenguang Shen, Rui Li, Zhide Guo, Shaowei Li, Qingbing Zheng, Chengchao Chu, Zhantong Wang, Zizheng Zheng,  Rui Tian, Shengxiang Ge, Xianzhong Zhang, Ningshao Xia, Gang Liu* and Xiaoyuan Chen*. Virus-Mimetic Nanovesicles as a Versatile Antigen Delivery System. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015, 112(45): E6129-E6138. (IF 9.674)

3.Xiao-Rong Song#, Xiaoyong Wang#, Shu-Xian Yu, Jianbo Cao, Shi-Hua Li, Juan Li, Gang Liu*, Huang-Hao Yang*, and Xiaoyuan Chen. Co9Se8 Nanosheets as a new Theranostic Platform for Photoacoustic/Magnetic Resonance Dual-Modal Imaging Guided Chemo-Photothermal Combination Therapy. Adv Mater. 2015, 27(21):3285-91. (IF 17.493)

4.Xiaoyong Wang#, Yun Zeng#, Don N. Ho#, Juan Yin, Gang Liu*, and Xiaoyuan Chen. Fibroblast Growth Factor-Inducible 14: Multiple Roles in Tumor Metastasis. Curr Mol Med. 2015, 15(10): 892-904. (IF 3.621)

5.Yong Wang, Tao Yang, Hengte Ke, Aijun Zhu, Yangyun Wang, Junxin Wang, Junkang Shen, Gang Liu, Chunying Chen, Yuliang Zhao and Huabing Chen*.  Smart Albumin-Biomineralized Nanocomposites for Multimodal Imaging and Photothermal Tumor Ablation. Adv Mater. 2015, 27(26):3874-82 (IF 17.493)

6.Jie Huang, Miao Guo, Hengte Ke, Cheng Zong, Bin Ren*, Gang Liu, He Shen, Yufei Ma, Xiaoyong Wang, Hailu Zhang, Zongwu Deng, Huabing Chen*, and Zhijun Zhang*. Rational Design and Synthesis of γFe2O3@Au Magnetic Gold Nanoflowers for Efficient Cancer Theranostics. Adv Mater. 2015, 27(34):5049-56.(IF 17.493)

7.Saheel Bhana#, Gan Lin#, Lijia Wang, Hunter Starring, Sanjay R Mishra, Gang Liu*, and Xiaohua Huang*. Near Infrared-absorbing Gold Nanopopcorns with Iron Oxide Cluster Core for Magnetically Amplified Photothermal and Photodynamic Cancer Therapy. ACS Appl Mater Interfaces. 2015, 7(21):11637-47. (IF 6.723)

8.Wen Cai, Chengchao Chu, Gang Liu*, and Yixiang Wang*. Metal-Organic Framework-Based Nanomedicine Platforms for Drug Delivery and Molecular Imaging. Small. 2015, 11(37):4806-22. (IF 8.368)

9.Congqing Zhu, Yuhui Yang, Ming Luo, Caixia Yang, Jingjing Wu, Lina Chen, Gang Liu, Tingbin Wen, Jun Zhu*, and Haiping Xia*. Stabilizing Two Classical Antiaromatic Frameworks: Demonstration of Photoacoustic Imaging and the Photothermal Effect in Metallaaromatics. Angew Chem Int Ed. 2015, 54(21):6181-5. (IF 11.261)

10.Yan Tan#, Lisi Xie#, Zhiyong Wang*, Na Zhang, Chao Zou, Zhi-ying Chen, Xin Liu, Jian Lu, Gang Liu, and Hairong Zheng*. Epsilon-caprolactone modified polyethylenimine for highly efficient antigen delivery and chemical exchange saturation transfer functional MR imaging. Biomaterials. 2015, 36(56): 219-28 (IF 8.557)

11.Wenbin Zeng*, Xiaobo Wang, Pengfei Xu, Gang Liu, Henry S. Eden, and Xiaoyuan Chen*. Molecular Imaging of Apoptosis: From Micro to Macro. Theranostics. 2015, 5(6):559-582. (IF 8.022)

12.Shujing Liang, Chao Li, Chunlei Zhang, Yunsheng Chen, Liang Xu, Chenchen Bao, Xiaoyong Wang, Gang Liu, Fengchun Zhang*, and Daxiang Cui*. CD44v6 Monoclonal Antibody-Conjugated Gold Nanostars for Targeted Photoacoustic Imaging and Plasmonic Photothermal Therapy of Gastric Cancer Stem-like Cells. Theranostics. 2015, 5(9): 970-984. (IF 8.022)

13.Junqing Wang, Pengfei Zhang, Chao Huang, Gang Liu, Ken Cham-Fai Leung*, and Yi-Xiang J. Wang*. High Performance Photoluminescent Carbon dots for In-Vitro and In-Vivo Bioimaging: Effect of Nitrogen Doping Ratios. Langmuir. 2015, 31(29):8063-73. (IF 4.457)

14.Wei-Hai Chen, Qi Lei, Cai-Xia Yang, Hui-Zhen Jia, Guo-Feng Luo, Xiao-Yong Wang, Gang Liu, Si-Xue Cheng, and Xian-Zheng Zhang*. Bioinspired Nano-Prodrug with Enhanced Tumor Targeting and Increased Therapeutic Efficiency. Small. 2015, 11(39):5230-42.

15.Wei-Hai Chen, Cai-Xia Yang, Wen-Xiu Qiu, Guo-Feng Luo, Hui-Zhen Jia, Qi Lei, Xiao-Yong Wang, Gang Liu, Ren-Xi Zhuo and Xian-Zheng Zhang*. Multifunctional Theranostic Nanoplatform for Cancer Combined Therapy Based on Gold Nanorods. Advanced Healthcare Materials. 2015,4(15):2247-59.

16.Junqing Wang, Gang Liu, Ken Cham-Fai Leung, Romaric Loffroy, Pu-Xuan Lu and YìXiáng J. Wáng*. Opportunities and Challenges of Fluorescent Carbon Dots in Translational Optical Imaging. Current Pharmaceutical Design. 2015, 21(37):5401-16.

17.Chao Huang, Chengchao Chu, Jun Zhang, Haiyan Gao and Gang Liu*. Antitumor effect of sinoporphyrin sodium loaded graphene oxide on human liver cancer HepG2 cells. Photon Lasers Med. 2015, 4(4): 365-368.

18.Tingting Fu, Yuyan Chen, Jiali Hao, Xiaoyong Wang, Gang Liu, Yonggang Li,*    Zhuang Liu and Liang Cheng*. Facile preparation of uniform FeSe2 nanoparticles for PA/MR dual-modal imaging and photothermal cancer therapy. Nanoscale, 2015, DOI: 10.1039/C5NR06840A

19.Mengting Cai, Lei Ren, Xiaoqin Yin, Zhide Guo, Yesen Li, Tingting He, Yongxiang Tang, Tingting Long, Yutao Liu, Gang Liu, Xianzhong Zhang, Shuo Hu*. PET monitoring angiogenesis of infarcted myocardium after treatment with vascular endothelial growth factor and bone marrow mesenchymal stem cells Amino Acids. 2015, DOI: 10.1007/s00726-015-2129-4

20.曹健波, 付贵峰, 张帆, 刘刚*. 功能磁共振用于肿瘤光热和光动力协同治疗的实时监测研究[J], 福州大学学报(自然科学版). 2015, 43(5):722-726

21.彭乔立, 王骁勇, 黄超, 刘刚*. 碳量子点作为光声造影剂的性能评价与基础研究[J] , 福州大学学报(自然科学版). 2015, 43 (6):860-863

2014

22.Mei Chen, Shaoheng Tang, Zhide Guo, Xiaoyong Wang, Shiguang Mo, Xiaoqing Huang, Gang Liu*, and Nanfeng Zheng*. Core-Shell Pd@Au Nanoplates as Theranostic Agents for in vivo Photoacoustic Imaging, CT imaging Imaging and Photothermal Therapy. Adv Mater. 2014, 26 (48): 8210-6. (IF 17.493)

23.Li-Sen Lin, Zhong-Xiao Cong, Jian-Bo Cao, Kai-Mei Ke, Qiao-Li Peng, Jinhao Gao, Huang-Hao Yang*, Gang Liu*, and Xiaoyuan Chen. Multifunctional Fe3O4@Polydopamine Core-Shell Nanocomposites for Intracellular mRNA Detection and Imaging-Guided Photothermal Therapy. ACS Nano. 2014, 8 (4): 3876-83 (IF 12.881)

24.Liang Cheng*, Hua Gong, Wenwen Zhu, Jingjing Liu, Xiaoyong Wang, Gang Liu*, and Zhuang Liu*. PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy. Biomaterials, 2014, 35(37): 9844-52. (IF 8.557)

25.Jing Liu#, Liqin Wang#, Jianbo Cao, Yue Huang, Yu Lin, Xiaoyun Wu, Zhiyong Wang, Fan Zhang, Xiuqin Xu*, and Gang Liu*. Functional investigations on embryonic stem cells labeled with clinically translatable iron oxide nanoparticles. Nanoscale, 2014, 6 (15): 9025-33 (IF 7.394)

26.Liqin Wang#, Xiaoyong Wang#, Ashwinkumar Bhirde, Jianbo Cao, Yun Zeng, Xinglu Huang, Yaping Sun, Gang Liu*, and Xiaoyuan Chen*. Carbon dots based two-photon visible nanocarriers for safe and highly efficient delivery of siRNA and DNA. Adv Healthc Mater. 2014. 3(8):1203-9. (Cover paper) (IF 5.797)

27.Yesen Li, Wei Zhang, Hua Wu, and Gang Liu*. Advanced tracers in PET imaging of cardiovascular disease. BioMed Research International. 2014, 2014: 504532 (IF 1.579)

28.Ki-Young Choi#, Xinglu Huang#, Oscar Ferreira Silvestre, Sang Wook Lee, Jong In Hong, Seulki Lee, Gang Liu, Don Ho, Naoki Hida and Xiaoyuan Chen*. A nanoparticle formula for delivering siRNA or miRNAs to tumor cells in cell culture and in vivo. Nature Protocols. 2014. 9(8):1900-15. (IF 9.673)

29.Rong He#, You-Cheng Wang#, Xiaoyong Wang#, Zhantong Wang, Gang Liu, Wei Zhou, Longping Wen, Qunxiang Li, Xiaoping Wang, Xiaoyuan Chen, Jie Zeng* and Jianguo Hou. Facile Synthesis of Pentacle Au-Cu Alloy Nanocrystals and their Plasmonic and Catalytic Properties. Nature Communications. 2014, 5:4327. (IF 11.47)

30.Houdong Zuo, Wei Yao, Tianwu Chen, Jiang Zhu, Juan Zhang, Yu Pu, Gang Liu and Xiaoming Zhang*. The Effect of Superparamagnetic Iron Oxide (SPIO) with iRGD Peptide on the Labeling of Pancreatic Cancer Cells In Vitro: A Preliminary Study. BioMed Research International. 2014, 2014: 852352 (IF 1.579)

31.Zipeng Zhen, Wei Tang, Yen-Jun Chuang, Trever Todd, Weizhong Zhang, Xin Lin, Gang Niu, Gang Liu, Lianchun Wang, Zhengwei Pan, Xiaoyuan Chen, and Jin Xie*. Tumor Vasculature Targeted Photodynamic Therapy for Enhanced Delivery of Nanoparticles. ACS Nano. 2014, 8(6):6004-13. (IF 12.881)

32.Zhiyong Wang, Gang Liu*, Hairong Zheng, and Xiaoyuan Chen*. Rigid nanoparticle-based delivery of anti-cancer siRNA: challenges and opportunities. Biotechnology Advances. 2014, 32(4):831-43. (IF 9.015)

33.Miao Guo, Huajian Mao, Yanli Li, Aijun Zhu, Hui He, Hong Yang, Yangyun Wang, Xin Tian, Cuicui Ge, Qiaoli Peng, Xiaoyong Wang, Xiangliang Yang, Xiaoyuan Chen, Gang Liu*, and Huabing Chen*. Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials. 2014, 35(16): 4656-4666. (IF 8.557)

34.Ruijun Xing, Gang Liu*, Jinghan Zhu, Yanglong Hou*, and Xiaoyuan Chen. Functional magnetic nanoparticles for non-viral gene delivery and MR imaging. Pharmaceutical Research. 2014, 31(6):1377-89. (IF 4.408)

35.Xuejiao Song, Hua Gong, Shengnan Yin, Liang Cheng, Chao Wang, Zhiwei Li, Yonggang Li, Xiaoyong Wang, Gang Liu, and Zhuang Liu*. Ultra-Small Iron Oxide Doped Polypyrrole Nanoparticles for In Vivo Multimodal Imaging Guided Photothermal Therapy. Advanced Functional Materials. 2014, 24(9):1194-1201 (IF 11.805)

36.Liang Cheng, Jingjing Liu, Xing Gu, Hua Gong, Xiaoze Shi, Teng Liu, Chao Wang, Xiaoyong Wang, Gang Liu, Huaiyong Xing, Wenbo Bu, Baoquan Sun and Zhuang Liu*. PEGylated WS2 Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual-Modal CT/Photoacoustic Imaging Guided Photothermal Therapy. Advanced Materials. 2014, 26(12):1886-1893  (IF 17.493)

37.Zhihui Wan, Huajian Mao, Miao Guo, Yanli Li, Aijun Zhu, Hong Yang, Junkang Shen, Lijuan Zhou, Zhen Jiang, Xiaoyuan Chen, Gang Liu, and Huabing Chen*. Highly Efficient Hierarchical Micelles Integrating Photothermal Therapy and Singlet Oxygen-Synergized Chemotherapy for Cancer Eradication. Theranostics   2014, 4(4): 399-411(IF 8.022)

38.Juan Hu, Xianglong Zhu, Hui Li, Zhenghuan Zhao, Xiaoqin Chi, Guoming Huang, Dengtong Huang, Gang Liu, Xiaomin Wang, and Jinhao Gao*. Theranostic Au Cubic Nano-aggregates as Potential Photoacoustic Contrast and Photothermal Therapeutic Agents. Theranostics. 2014, 4(5): 534-545(IF 8.022)

39.Longfa Xu, Delei He, Zhiqun Li, Jun Zheng, Lisheng Yang, Miao Yu, Hai Yu, Yixin Chen, Yuqiong Que, James Wai Kuo Shih, Gang Liu, Jun Zhang, Qinjian Zhao, Tong Cheng, and Ningshao Xia. Protection against Lethal Enterovirus 71 Challenge in Mice by a Recombinant Vaccine Candidate Containing a Broadly Cross-Neutralizing Epitope within the VP2 EF Loop. Theranostics. 2014; 4(5): 498-513(IF 8.022)

40.Pan Wang#, Yun Zeng#, Tao Liu, Chao Zhang*, Peiwu Yu, Yingxue Hao, Huaxin Luo, and Gang Liu. Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway. World Journal of Gastroenterology. 2014. 20(8): 2071-78 (IF 2.547)

41.Liming Nie, Shouju Wang, Xiaoyong Wang, Pengfei Rong, Ying Ma, Gang Liu, Peng Huang, Guangming Lu, Xiaoyuan Chen*. In Vivo Volumetric Photoacoustic Molecular Angiography and Therapeutic Monitoring with Targeted Plasmonic Nanostars. Small. 2014, 10(8):1585-93. (IF 8.368)

2013

42.Gang Liu*, Jin-hao Gao, Hua Ai, and Xiao-yuan Chen*. Applications and Potential Toxicity of Magnetic Iron Oxide Nanoparticles. Small. 2013;9(9):1533-45. (IF 8.368)

43.Gang Niu, Lei Zhu, Don N. Ho, Fan Zhang, Hao-kao Gao, Qi-meng Quan, Naoki Hida, Takeaki Ozawa, Gang Liu*, Xiao-yuan Chen. Longitudinal Bioluminescence Imaging of the Dynamics of Doxorubicin Induced Apoptosis. Theranostics 2013; 3(3):190-200 (Cover paper, IF 8.022)

44.Xiaoyong Wang#, Zijian Zhou#, Zhiyong Wang, Yunxin Xue, Yun Zeng, Jinhao Gao, Lei Zhu, Xianzhong Zhang, Gang Liu*, and Xiaoyuan Chen*. Gadolinium embedded iron oxide nanoclusters as T1-T2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery. Nanoscale. 2013; 5(17):8098-104 (IF 7.394)

45.Ye Xu#, Yun Zeng#, Yanhong Liu, Gang Liu*, and Hua Ai*. Endothelial cell targeted molecular imaging in tumor angiogenesis: strategies and current status. Current Pharmaceutical Biotechnology. 2013, 14(7): 644-57. (IF 3.049)

46.Lei Li, Lingling Jiang, Yun Zeng and Gang Liu*. Toxicity of superparamagnetic iron oxide nanoparticles: research strategies and implications for nanomedicine. Chinese Physics B. 2013, 22 (12): 127503 (IF 1.603)

47.Dingbin Liu, Zhantong Wang, Albert Jin, Xinglu Huang, Xiaolian Sun, Fu Wang, Qiang Yan, Shengxiang Ge, Ningshao Xia, Gang Niu, Gang Liu, A. R. HightWalker, and Xiaoyuan Chen*. Acetylcholinesterase-Catalyzed Hydrolysis Allows Ultrasensitive Detection of Pathogens with the Naked Eye. Angew Chem Int Ed Engl. 2013, 52(52):14065-9. (IF 11.261)

48.Yi-Wei Wang, Yu-Ying Fu, Qiaoli Peng, Shan-Shan Guo, Gang Liu, Juan Li, Huang-Hao Yang*, and Guo-Nan Chen. Dye-enhanced graphene oxide for photothermal therapy and photoacoustic imaging. Journal of Materials Chemistry B. 2013, 1: 5762-5767 (IF 4.726)

49.Zipeng Zhen, Wei Tang, Cunlan Guo, Hongmin Chen, Xin Lin, Gang Liu, Baowei Fei, Xiaoyuan Chen, Bingqian Xu, and Jin Xie*. Ferritin Nanocages to Encapsulate and Deliver Photosensitizers for Efficient Photodynamic Therapy against Cancer. ACS Nano. 2013;7(8):6988-96 (IF 12.881)

50.Xinglu Huang, Fan Zhang, Lei Zhu, Ki Young Choi, Ning Guo, Jinxia Guo, Kenneth Tackett, Parambath Anilkumar, Gang Liu, Qimeng Quan, Hak Soo Choi, Gang Niu, Ya-Ping Sun, Seulki Lee, and Xiaoyuan Chen*. Effect of Injection Routes on the Biodistribution, Clearance, and Tumor Uptake of Carbon Dots. ACS Nano. 2013;7(7):5684-93 (IF 12.881)

51.Lin Gao, Li-si Xie, Xiao-jing Long, Zhi-yong Wang*, Cheng-Yi He, Zhi-Ying Chen, Lei Zhang, Xiang Nan, Hu-long Lei, Xin Liu, Gang Liu, Jian Lu, Ben-sheng Qiu*. Efficacy of MRI visible iron oxide nanoparticles in delivering minicircle DNA into liver via intrabiliary infusion. Biomaterials. 2013;34(14):3688-96 (IF 8.557)

52.Yun Zeng, Gang Liu, Ying Ma, Xiao-yuan Chen, and Yoichiro Ito*. Organic-high ionic strength aqueous solvent systems for spiral counter-current chromatography: graphic optimization of partition coefficient. Journal of Liquid Chromatography & Related Technologies. 2013;36(4): 504-12 (IF 0.706)

53.Qian Wan, Lisi Xie, Lin Gao, Zhi-yong Wang*, Xiang Nan, Hu-long Lei, Xiao-jing Long, Zhi-Ying Chen, Cheng-Yi He, Gang Liu, Xin Liu and Ben-sheng Qiu*. Self-assemble Magnetic Theranostic Nanoparticles for Highly Sensitive MRI of Minicircle DNA Delivery. Nanoscale, 2013;5(2):744-52 (IF 7.394)

54.Rui-jun Xing, Ashwinkumar A Bhirde, Shou-ju Wang, Xiao-lian Sun, Gang Liu, Yang-long Hou, and Xiao-yuan Chen*. Hollow Iron Oxide Nanoparticles as Multidrug Resistant Drug Delivery and Imaging Vehicles. Nano Research, 2013;6(1):1-9 (IF 7.392)