周子健，教授 / 博士生导师
研究领域：分子影像学、纳米医学
研究兴趣：分子功能影像探针、磁共振成像、化学生物学、炎症免疫疾病、纳米医学
通信地址：福建省厦门市翔安区翔安南路4221-116号厦门大学翔安校区分子影像大楼306室
电 话：0592-2880649
邮 箱：zhouz@xmu.edu.cn
个人简介：
周子健博士于2015年在厦门大学化学化工学院获得化学生物学博士学位（导师：高锦豪教授），2015-2020年在美国国立卫生研究院（NIH）从事访问和博士后研究工作（导师：Xiaoyuan (Shawn) Chen，现为新加坡国立大学终身教授）。自2020年10月起在厦门大学担任独立课题组组长、博士生导师，分子疫苗学和分子诊断学国家重点实验室固定成员。
传统分子影像策略对生命活动中关键作用小分子/离子的活体成像能力不足。课题组针对水分子、铁离子和活性氧小分子的磁共振成像和调控研究，在肿瘤成像“看得清”、治疗监测“分得开”、以及预后评价“测得准”三个方面取得了具有特色的研究成果，实现了铁死亡相关疾病的早期成像评估和治疗指导，以及免疫细胞功能和活性的可视化调控和诊疗应用。迄今，共发表学术论文80余篇，撰写英文专著章节1章，据Web of Science统计论文总被引用9000余次、H因子50。其中，以第一/通讯（含共同）作者在Nat. Nanotechnol.（最后通讯1篇）、Sci. Adv.（最后通讯1篇）、Nat. Commun.（2篇）、Adv. Mater.（4篇）、Angew. Chem. Int. Ed.（4篇）、ACS Nano（5篇）、J. Am. Chem. Soc.、Chem. Soc. Rev.等发表多篇论文，多篇入选ESI高被引论文，单篇最高被引用大于1000次。曾获得美国国立卫生研究院（NIH）“卓越研究员奖”（Fellows Award for Research Excellence, FARE）、教育部“王宽诚教育基金会”会议基金资助，担任iRADIOLOGY等杂志青年编委，入选“南强青年拔尖人才”计划、福建省高层次人才（海外引进）等。作为博士后合作导师指导1名博士后获得2021年“博新计划”。现担任10余种国际学术期刊的独立审稿人。
研究方向：
一、肿瘤氧化还原微环境的可视化调控和肿瘤诊疗研究；
二、铁死亡途径分子影像探针的开发及其相关疾病的诊疗应用；
三、纳米药物的临床转化工艺和药效评估。
主要论文（*通讯作者，†共同一作）：
29. Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics. Shi, C.; Zhang, Q.; Yao, Y.; Zeng, F.; Du, C.; Nijiati, S.; Wen, X.; Zhang, X.; Yang, H.; Chen, H.; Guo, Z.; Zhang, X.; Gao, J.; Guo, W.*; Chen, X.*; Zhou, Z.* Nat. Nanotechnol. 2023, 18, 86-97.
28. Ferroptosis MRI for Early Detection of Anticancer Drug-Induced Acute Cardiac/Kidney Injuries. Zeng, F.; Nijiati, S.; Liu, Y.; Yang, Q.; Liu, X.; Zhang, Q.; Chen, S.; Su, A.; Xiong, H.; Shi, C.; Cai, C.; Lin, Z.; Chen, X.*; Zhou, Z.* Sci. Adv. 2023, 9, eadd8539.
27. Ferroptosis Detection: From Approaches to Applications. Zeng, F.; Nijiati, S.; Tang, L.; Ye, J.; Zhou, Z.*; Chen, X.* Angew. Chem. Int. Ed. 2023, e202300379. (Invited Review)
26. Boosting the Immunoactivity of T Cells by Resonant Thermal Radiation from Electric Graphene Films for Improved Cancer Immunotherapy. Shi, C.; Fu, W.; Zhang, X.; Zhang, Q.; Zeng, F.; Nijiati, S.; Du, C.; Liu, X.; Wang, M.; Yao, Y.; Huang, H.; Zheng, N.; Chen, X.; Wu, B.*; Zhou, Z.* Adv. Therap. 2023, 2200163.
25. Coordinating the Mechanisms of Action of Ferroptosis and Photothermal Effect for Cancer Theranostics. Zeng, F.; Tang, L.*; Zhang, Q.; Shi, C.; Huang, Z.; Nijiati, S.; Chen, X.*; Zhou, Z.* Angew. Chem. Int. Ed. 2022, 61, e202112925.
24. Cycloacceleration of Reactive Oxygen Species Generation Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for Tumor Ferroptosis Therapy. Zhou, H.; Lu, X.; Du, C.; Zhou, Z.*; Feng, J.; Liang, Z.; Xu, Y.*; Qiu, X.*; Shen, Z.* Small 2022, 18, e202202705.
23. Exquisite Vesicular Nanomedicine by Paclitaxel Mediated Co-assembly with Camptothecin Prodrug. Zhou, Z.*; Du, C.; Zhang, Q.; Yu, G.; Zhang, F.*; Chen, X.* Angew. Chem. Int. Ed. 2021, 60, 21033-21039.
22. Imaging beyond Seeing: Early Prognosis of Cancer Treatment. Shi, C.; Zhou, Z.*; Lin, H.*; Gao, J.* Small Methods 2021, 6, 2001025. (Review Article, Special Issue for the 100th Anniversary of the Xiamen University).
21. Targeting Neutrophils for Enhanced Cancer Theranostics. Tang, L.; Wang, Z.; Mu, Q.; Yu, Z.*; Jacobson, O.; Li, L.; Yang, W.; Huang, C.; Kang, F.; Fan, W.; Ma, Y.; Wang, M.*; Zhou, Z.*; Chen, X.* Adv. Mater. 2020, 32 (33), 2002739.
20. Early stratification of radiotherapy response by activatable inflammation magnetic resonance imaging. Zhou, Z.; Deng, H.; Yang, W.; Wang, Z.; Lin, L.; Munasinghe, J.; Jacobson, O.; Liu, Y.; Tang, L.; Ni, Q.; Kang, F.; Liu, Y.; Niu, G.; Bai, R.; Qian, C.; . Song, J.*; Chen, X.* Nat. Commun. 2020, 11, 3032.
19. Artificial Local Magnetic Field Inhomogeneity Enhances T2 Relaxivity. Zhou, Z.†; Tian, R.†; Wang, Z. Y.; Yang, Z.; Liu, Y. J.; Liu, G.; Wang, R. F.; Gao, J. H.; Song, J.*; Nie, L.*; Chen, X.*, Nat. Commun. 2017, 8, 15468.
18. Synchronous Chemoradiation Nanovesicles by X-ray Triggered Cascade of Drug Release. Zhou, Z.; Chan, A.; Wang, Z.; Huang, X.; Yu, G.; Jacobson, O.; Wang, S.; Liu, Y.; Shan, L. L.; Dai, Y.; Shen, Z.; Lin, L. S.; Chen, W.; Chen, X.* Angew. Chem. Int. Ed. 2018, 57, 8463-8467.
17. Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy. Zhou, Z.†; Song, J.†; Tian, R.; Yang, Z.; Yu, G.; Lin, L.; Zhang, G.; Fan, W.; Zhang, F.; Niu, G.; Nie, L.*; Chen, X.*, Angew. Chem. Int. Ed. 2017, 56, 6592-6596. (ESI Highly Cited Paper)
16. Structure–Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging. Zhou, Z.; Yang, L.; Gao, J.*; Chen, X.* Adv. Mater. 2019, 31, 1804567. (Review Article) (ESI Highly Cited Paper)
15. Reactive Oxygen Species Generating Systems Meeting Challenges of Photodynamic Cancer Therapy. Zhou, Z.; Song, J.; Nie, L.*; Chen, X.*, Chem. Soc. Rev. 2016, 45, 6597-6626. (Review Article) (ESI Highly Cited Paper)
14. Dancing with Reactive Oxygen Species Generation and Elimination in Nanotheranostics for Disease Treatment. Zhou, Z.*; Ni, K.; Deng, H.; Chen, X.* Adv. Drug Deliv. Rev. 2020, 158, 73-90. (Invited Review: ADDR Special Theme Issue “Advanced Drug Delivery 2020”)
13. Self-Assembled Responsive Bilayered Vesicles with Adjustable Oxidative Stress for Enhanced Cancer Imaging and Therapy. Song, J.; Lin, L.; Yang, Z.; Zhu, R.; Zhou, Z.*; Li, Z.*; Wang, F.; Chen, J.; Yang, H.*; Chen, X.* J. Am. Chem. Soc. 2019, 141, 8158.
12. Emerging Strategies of Cancer Therapy Based on Ferroptosis. Shen, Z.; Song, J.; Yung, B; Zhou, Z.*; Wu, A.*; Chen, X.*, Adv. Mater. 2018, 30, 1704007. (Review Article) (Featured as Frontispiece Article) (ESI Highly Cited Paper)
11. A Logic-Gated Modular Nanovesicle Enables Programmable Drug Release for On-Demand Chemotherapy. Tang, L.; Yang, Z.; Zhou, Z.*; Ma, Y.; Kiesewetter, D.; Wang, Z.; Fan, W.; Zhu, S.; Zhang, M.; Tian, R.; Lang, L.; Niu, G.; Zhang, X.*; Chen, X.* Theranostics. 2019, 9, 1358-1368.
10. T1–T2 Dual–Modal Magnetic Resonance Imaging: From Molecular Basis to Contrast Agents. Zhou, Z.; Bai, R.; Munasinghe, J.; Shen, Z.; Nie, L.*; Chen, X.*, ACS Nano 2017, 11, 5227–5232. (Perspective)
9. Tale of Two Magnets: An Advanced Magnetic Targeting System. Zhou, Z.; Shen, Z.*; Chen, X.* ACS Nano 2020, 14, 7-11. (Perspective)
8. An Albumin-Binding T1-T2 Dual-modal MRI Contrast Agents for Improved Sensitivity and Accuracy in Tumor Imaging. Zhou, Z.; Bai, R.*; Wang, Z.; Bryant, H.; Lang, L.; Merkle, H.; Munasinghe, J.; Tang, L.; Tang, W.; Tian, R.; Yu, G.; Ma, Y.; Niu, G.; Gao, J.*; Chen, X.* Bioconjugate Chem. 2019, 30, 1821-1829.
7. Water Bridge Coordination on The Metal-Rich Facets of Gd2O3 Nanoplates Confers High T1 Relaxivity. Zhou, Z.; Hu, R.; Wang, L.; Sun C.; Fu, G.; Gao, J.*, Nanoscale 2016, 45, 17887-17894.
6. Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography. Zhou, Z.†; Wu, C. Q.†; Liu, H. Y.; Zhu, X. L.; Zhao, Z.; Wang, L.; Xu, Y.; Ai, H.; Gao, J. H.*, ACS Nano 2015, 9, 3012-3022.
5. Anisotropic Shaped Iron Oxide Nanostructures: Controlled Synthesis and Proton Relaxation Shortening Effects. Zhou, Z.; Zhu, X. L.; Wu, D.; Chen Q.; Huang, D.; Sun, C.; Xin, J.; Ni, K. Y.; Gao, J.*, Chem. Mater. 2015, 27, 3505-3515.
4. A Protein-Corona-Free T1–T2 Dual-Modal Contrast Agent for Accurate Imaging of Lymphatic Tumor Metastasis. Zhou, Z.†; Liu, H.†; Chi, X.†; Chen, J.; Wang, L.; Sun, C.; Chen, Z.; Gao, J. H.*, ACS Appl. Mater. Interfaces 2015, 7, 28286.
3. Interplay between Longitudinal and Transverse Contrasts in Fe3O4 Nanoplates with (111) Exposed Surfaces. Zhou, Z.†; Zhao, Z.†; Zhang, H.; Wang, Z.; Chen, X. Y.; Wang, R.; Chen, Z.; Gao, J. H.*, ACS Nano 2014, 8, 7976-7985.
2. Engineered Iron-Oxide-Based Nanoparticles as Enhanced T1 Contrast Agents for Efficient Tumor Imaging. Zhou, Z.; Wang, L. R.; Chi, X.; Bao, J. F.; Yang, L.; Zhao, W.; Chen, Z.; Wang, X.; Chen, X. Y.; Gao, J. H.*, ACS Nano 2013, 7, 3287-3296.
1. A Synergistically Enhanced T1-T2 Dual-Modal Contrast Agent. Zhou, Z.; Huang, D. T.; Bao, J.; Chen, Q. L.; Liu, G.; Chen, Z.; Chen, X. Y.; Gao, J. H.*, Adv. Mater. 2012, 24, 6223-6228.
Book Chapter
1. Zhou, Z.; Chen, X.*, Magnetic Nanomaterials for Diagnostics in Magnetic Nanomaterials-Fundamentals, Synthesis and Applications, 365-392. Editor: Yanglong Hou, John Wiley & Sons (2017)