张阳，副教授

通信地址：福建省厦门市翔安区翔安南路4221-116号厦门大学翔安校区分子影像大楼309室

邮       编：361102

电      话：0592-2880648

电子邮箱: zhangyang0823@xmu.edu.cn

研究方向: 分子影像探针、仿生递送系统、基因精准治疗

个人简介：

张阳博士现为厦门大学公共卫生学院副教授，入选南强拔尖人才支持计划。2021年毕业于厦门大学，获理学博士学位（导师刘刚教授）；2022.09-2026.05在哈佛医学院Prof. Jinjun Shi（AIMBE Fellow）课题组从事博士后研究。研究方向聚焦于功能自组装制剂的设计及其生物医学应用，目标是利用分子与材料的自发组装原理，构建兼具精准递送与高效治疗特性的纳米体系，系统开展了两方面研究：功能自组装载体体系，如蛋白纳米笼、细胞膜囊泡、纳米脂质体等，用于小分子与核酸药物的精准高效递送；自组装纯药体系，如阿霉素、ICG、氯化钠等无载体自组装纯药，实现诊疗一体化与药效增强，已开展多项IIT临床研究，为肿瘤治疗与生物医学转化提供了新策略。迄今以第一作者/通讯作者身份（含共同）在Nature Communications、Chemical Society Reviews、Cell Biomaterials、Bioactive Materials、ACS Nano等国际知名学术期刊发表论文30余篇；申请专利9项，其中授权5项，3项进行企业技术转移和临床转化。曾获得福建省自然科学奖二等奖、第九届福建省互联网+金奖以及国家自然科学基金青年项目、深圳市自然科学基金面上项目等资助5项。

代表性论著：

1.Xuqi Peng†, Xiran Gui†, Yating Zheng†, Zhenwen Zhao, Yihang Yuan, Yisheng Peng, Haitao Cai, Jinyang Wang, Jianlin Ge, Hui Liu, Haitian Tang, Fan Dai, Aijun Jiang, Ruirui Fan, Yesi Shi, Chengchao Chu, Pan He*, Yang Zhang*, Gang Liu*. Fully active zinc nitroprusside nanomedicine transforms cisplatin into chemoimmunotherapeutic agent for robust hepatocellular carcinoma therapy. Cell Biomaterials, 2026, 2, 100338.

2.Yihang Yuan#, Weijie Sun#, Jiaqi Xie#, Ziheng Zhang, Jing Luo, Xiangfei Han, Yongfu Xiong*, Yang Yang*, Yang Zhang*, RNA nanotherapeutics for hepatocellular carcinoma treatment. Theranostics. 2025, 15(3):965-992.

3.Yang Zhang#, Jing Luo#, Xiran Gui#, Yating Zheng, Eric Schaar, Gang Liu*, Jinjun Shi*. Bioengineered Nanotechnology for Nucleic Acid Delivery. Journal of Controlled Release. 2023, 364: 124-141.

4.Yang Zhang#, Hongwei Cheng#, Hu Chen#, Peiyao Xu #, En Ren, Yonghe Jiang, Dengfeng Li , Xing Gao , Yating Zheng , Pan He , Huirong Lin, Biaoqi Chen, Gan Lin, Aizheng Chen, Chengchao Chu *, Jingsong Mao*, Gang Liu*. A pure nanoICG-based homogeneous lipiodol formulation: Toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization. European Journal of Nuclear Medicine and Molecular Imaging. 2022, 49(8):2605-2617.

5.Yang Zhang, Xiaoyong Wang, Chengchao Chu, Zijian Zhou, Biaoqi Chen, Xin Pang, Gan Lin, Huirong Lin, Yuxin Guo, En Ren, Peng Lv, Yesi Shi, Qingbing Zheng, Xiaohui Yan, Xiaoyuan Chen, and Gang Liu*. Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics. Nature Communications. 2020, 11 5421.

6.Yating Zheng#, Yulan Huang#, Jing Luo#, Xuqi Peng, Xiran Gui, Gang Liu *, Yang Zhang*. Supercritical fluid technology: A game-changer for biomacromolecular micro-nanomedicine preparation and biomedical application. Chinese Chemical Letters. 2023, 109169.

7.Xuqi Peng#, Yating Zheng#, Yi Xue#, Xiaoliu Liang#, Pan He, Hu Chen, Peng He, Yisheng Peng, Zhenwen Zhao, Yulun Chen, Xiran Gui, Lei Yang, Yongfu Xiong, Juan Lin, Yesi Shi, Chengchao Chu, Yang Zhang*, and Gang Liu*, Super-stable homogeneously sustained-release system mediates transcatheter arterial ionic-embolization strategy for hepatocellular carcinoma therapy. Advanced Functional Materials. 2023, 202311505.

8.Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li，Junjie Lin, Zihan Xie, Xutong Li, Haotian Li, Kexing Han, Yang Zhang*, Jiabin Li*, Yufeng Gao*. TRIM47 regulates energy metabolism via glycolytic reprogramming to drive hepatocellular carcinoma progression and represents an efficient therapeutic target. Advanced Science, 2026, e16996.

9.Fangjian Li, Zixiang Tang, Yating Zheng, Tao Jiang, Lin Deng, Wenjie Dai, Yuxing Zhao, Nan Zheng, Siman Liu, Yuxuan Fan, Sihan Lu, Yanxi Chen, Gang Liu*, Yang Zhang*, Yongfu Xiong*. Responsive Nanomedicine Strategies Achieve Pancreatic Cancer Precise Theranostics. Bioactive Materials. 2026,55, 334-375.

10.Xuqi Peng#, Haitian Tang#, Zhenwen Zhao#, Yating Zheng#, Xiran Gui, Aijun Jiang, Pan He, Xiaofei Wen, Qian Zhang, Ziyang Mei, Yesi Shi, Chengchao Chu, Yang Zhang*, Gang Liu*. Intelligent Generic High-Throughput Oscillatory Shear Technology Fabricates Programmable Microrobots for Real-Time Visual Guidance During Embolization. Small. 2024, 202408613.

11.Yonghe Jiang#, Xuqi Peng#,*, Yulun Chen, Biaoqi Chen, Yating Zheng, Haitao Cai, Xiran Gui, Hongwei Cheng, Zhixiang Lu, Jingsong Mao*, Yang Zhang*, Gang Liu*, An additive-free lipiodol-drugs formulation makes surgery for advanced hepatocellular carcinoma feasible through downstaging and fluorescence navigation. Chinese Chemical Letters,2026,113031.

12.Shuang Bai#, Zhixiang Lu#, Yonghe Jiang, Xiaoxiao Shi, Dazhuang Xu, Yesi Shi, Gan Lin, Chao Liu, Yang Zhang*, Gang Liu*. Nanotransferrin-based programmable catalysis mediates three-pronged induction of oxidative stress to enhance cancer immunotherapy. ACS Nano. 2021, 16(1): 997–1012.

13.Liyi Fu#, Yang Zhang#, Ryan A. Farokhzadb, Bárbara B. Mendesc, João Condec, and Jinjun Shi*. ‘Passive’ Nanoparticles for Organ-Selective Systemic Delivery: Design, Mechanism and Perspective. Chemical Society Reviews. 2023, 52, 7579-7601.

14.Songsong Jiang, Ziheng Zhang, Yongfei Mao, Xiangwei Xia, Jing Luo*, Yang Zhang*, Yihang Yuan*. Emerging nano-immunotherapeutic strategies achieve metastatic colorectal precision therapy. Journal of Nanobiotechnology, 2026 ,24 ,111.

15.Peng He, Sha Yi, Jianzhong Zhang, Chengchao Chu, Xuqi Peng, Changhong Li, Xinfei Sun, Yang Zhang*, Hongwei Cheng*, Xia Xiong*, Gang Liu*. Carrier-free 5-Fu nanoparticle-mediated domestication therapy for scar treatment: A preclinical and first-in-human study, Chemical Engineering Journal. 2023, 475, 146061.

16.Pan He#, En Ren#, Biaoqi Chen#, Hu Chen#, Hongwei Cheng, Xing Gao, Xiaoliu Liang, Hao Liu, Jingdong Li, Bo Li, Aizheng Chen, Chengchao Chu, Jingsong Mao*, Yang Zhang*, Gang Liu*. A super-stable homogeneous lipiodol-hydrophilic chemodrug formulation for hepatocellular carcinoma. Theranostics. 2022, 12(4):1769-1782.

17.Xiaohan Zheng; Jingying Zhuang; Xinyan Peng; Yang Zhang*; Dezhao Chen*; Bing Chen*. DNA nanotherapeutics facilitate efficient gynecological cancers treatment. Journal of Controlled Release. 2025, 388, 114336.

18.Pan He#, Yongfu Xiong#, Jinfa Ye#, Biaoqi Chen, Hongwei Cheng, Hao Liu, Yating Zheng, Chengchao Chu, Jingsong Mao, Aizheng Chen, Yang Zhang*, Jingdong Li*, Jie Tian*, Gang Liu*. A clinical trial of super-stable homogeneous lipiodol-nanoICG formulation-guided precise fluorescent laparoscopic hepatocellular carcinoma resection. Journal of Nanobiotechnology. 2022, 20(1): 250.

19.Ryan A. Farokhzad, Jing Luo, Li Jia, Yang Zhang*, Jinjun Shi*. Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer. ACS Nanoscience Au. 2024, 5(4): 284-292.

20.Dong Li *, Shundong Cai, Peiyu Wang, Hongwei Cheng, Bingwei Cheng, Yang Zhang*, Gang Liu *. Innovative design strategies advance biomedical applications of phthalocyanines. Advanced Healthcare Materials. 2023, 12(22):e2300263.