李进典 博士
合作导师：张现忠教授
李进典博士致力于心脑血管疾病和肿瘤相关核素显像探针的设计、合成及和生物学应用研究。研究内容主要包括（1）设计合成靶向脑卒中及心肌缺血再灌注损伤的特异性分子探针并考察其显像效果及规律；（2）设计合成靶向肿瘤免疫微环境的核素标记小分子探针并考察其肿瘤显像和治疗效果。迄今以第一作者身份在Theranostics, Analytical Chemisty, Molecular Pharmaceutics等国际学术刊物上发表论文5篇，共同署名身份在Science Advances，Nature Communications等国际学术期刊发表论文10余篇，获得授权发明专利1项。
教育背景：
2008.09 – 2012.06：大理大学，药学专业，获理学学士学位
2013.09 – 2016.06：中国药科大学，药学专业，获理学硕士学位，导师殷志琦和张健教授
2016.09 – 2021.06：厦门大学，生物化学与分子生物学专业，导师张现忠教授
2018.11 – 2020.11：美国南加利福尼亚大学核医学科公派留学，导师陈凯教授
发表论文：
1. Li J, Valkenburgh J, Conti P, Chen K. Exploring Solvent Effects in the Radiosynthesis of 18F-Labeled Thymidine Analogues toward Clinical Translation for Positron Emission Tomography Imaging. ACS Pharmacology Translational Science. 2020, 4:266-275.
2. Li J, Valkenburgh J, Hong X, Conti P, Zhang X, Chen K. Small molecules as theranostic agents in cancer immunology. Theranostics. 2019, 9(25): 7849-7871.
3. Li J, Hong X, Li G, Conti P, Zhang X, and Chen K. PET Imaging of adenosine receptors in diseases. Current Topics in Medicinal Chemistry. 2019, 19: 1445-1463.
4. Li J, Peng C, Guo Z, Shi C, Zhuang R, Hong X, Wang X, Xu D, Zhang P, Zhang D, Liu T, Su X, and Zhang X. Radioiodinated Pentixather for SPECT Imaging of Expression of the Chemokine Receptor CXCR4 in Rat Myocardial-Infarction−Reperfusion Models. Analytical Chemisty. 2018, 90: 9614-9620.
5. Li J, Zhang J, Yang S, Jiang C, Zhang D, Jin Q, Wang Q, Wang C, Ni Y, Yin Z, and Song S. Synthesis and preclinical evaluation of radioiodinated hypericin dicarboxylic acid as a necrosis avid agent in rat models of induced hepatic, muscular and myocardial necroses. Molecular Pharmaceutics. 2016, 13(1): 232-240.
6.Yang P,† Chou S,† Li J, Hui W, Liu W, Sun N, Zhang RY, Zhu Y, Tsai ML, Lai HI, Smalley M, Zhang X, Chen J, Romero Z, Liu D, Ke Z, Zou C, Lee C, Jonas SJ, Ban Q, Weiss PS, Kohn DB, Chen K, Chiou SH, and Tseng HR. Supramolecular Nanosubstrate-Mediated Delivery System Enables CRISPR/Cas9 Knockin of Hemoglobin Beta Gene for Hemoglobinopathies. Science Advances. 2020; 6: eabb7107.